Why take Methylene Blue with Liposomal Absorption

Methylene Blue (MB) is a unique electron cycler, capable of both donating and accepting electrons.  Once absorbed MB concentrates in tissues with high mitochondrial density, including the brain (where it readily crosses the blood-brain barrier), heart, liver and kidneys.

At low doses, MB unlocks remarkable cellular benefits.  Here is how MB supports cellular function:

• Optimises Mitochondrial Efficiency - by accelerating cytochrome oxidase (complex IV) activity, MB increases oxygen consumption and ATP (Adenosine Triphosphate) production, particulary benefiting high-energy cells like neurons.  ATP is the energy currency of the cell.
• Enhances ATP (energy) Production - MB donates electrons to the electron transport chain (ETC), boosting adenosine triphosphate (ATP) production.  This effect occurs even in low-oxygen conditions.
• Supports Glucose Metabolism & NAD + Production -  MB enhances glucose metabolism in anaerobic conditions and increases NAD + levels, which may promote cellular longevity via sirtuin activation.
• Acts as a Potent Antioxidant - as a free radical scavenger, MB protects mitochondria and cells from oxidative stress, potentially offering neuroprotection and skin health benefits.
• Boosts Mood & Neurotransmitters - MB functions as a monoamine oxidase (MAO) inhibitor, preventing the breakdown of dopamine, serotonin and melatonin, which may contribute to its antidepressant properties.
• Improves Oxygen Delivery - MB alters hemoglobin's iron (heme) configuration in red blood cells, enhancing oxygen-carrying capacity and further driving ATP syntheses.
• Enhances Cognitive Function - By inhibiting cholinesterase, MB increases acetylcholine levels, supporting memory, attention and motivation.
• Supports Antimicrobial Defense - When combined with specific light spectrums (primarily UV), MB may exhibit antiviral and antibacterial properties.

Warning

Methylene Blue and Safety

MB has been used safely over a century, but high doses (>3 mg/kg) of prolonged use can be toxic.  It may also disrupt biofilms and have a long half-life.

Do not take MB if you:

• have hepatic or renal impairment
• are pregnant or breastfeeding
• have a sensitivity to methylene blue or thiazine dyes
• are using SSRIs, SNRIs, psychedelics or other serotonin-reuptake inhibitors, as this can cause serotonin syndrom.

Keep away from children and animals.

Methylene Blue and Biofilms

Higher doese of low-dose methylene blue (> 1mg/kg) may disrupt healthy gut biofilms, potentially harming gut lining and microbiota.  Biofilms are communities of microorganisms (bacteria, fungi, rotists) that form protective layers on surfaces, including in the gut.  They create a sticky substance (EPS) that helps them stick together and exchange genetic material.  In the gut, biofilms support immunie function and protect the intestinal lining.  However, some biofiilms, like dental plaque or bacterial infections, can become harmful, as they shield harmful bacteria.  Methylene blue can break down biofilms, especially when used with photodynamic therapy.  It's sometimes used in higher does (50mg twice daily) for infections like Bartonella.

When to take Methylene Blue
The best time to take Methylene Blue (MB) depends on your goals and how you are using it.  Here are some general guidelines:

1. Cognitive Enhancements & Energy Boost Best Times: morning or early afternoon why: MB enhances mitochondrial function, ATP production, and cognitive performance.  Taking it in the morning helps avoid interference with sleep.
2. Mood & Mental Clarity Best Time: Morning or mid-day Why? MB has mild MAO inhibition properties, which can improve mood and focus.  Taking it earlier aligns with natural dopamine and serotonin rhythms.
3. Neuroprotection & Longevity: any time (with food for better absorption), why: if using it for long-term brain health, consistency matters more than timing.
4. Antimicrobial & Antiviral Support: Spread out through the day in divided doese.  Why? This maintains a steady pesence in the bloodstream to combat infeciton.
5. Exercise & Performance Enhancement: 30 - 60 minutes before exercies.  Why? MB improves oxygen utilisation and mitochondrial effiency, leading to better endurance and recovery.

We are delighted to offer free shipping on all orders over R1500.

Delivery Services:
Lifestyle Health utilises The Courier Guy and Aramex for all our deliveries within South Africa. Once your order is dispatched, you will receive a tracking number to monitor the progress of your shipment.

Order Processing:
Orders are processed during regular business hours. If an order is placed on a weekend or public holiday, it will be processed on the next business day.
Orders are dispatched within 1-2 working days.

Delivery Timeframe:
Our goal is to ensure you receive your order as quickly as possible. Orders are typically delivered within 2-5 working days, depending on the delivery location within South Africa. We strive to process all orders promptly upon receipt.
Courier delivery takes 2 – 5 working days depending on the order's destination.

• Deliveries are made Monday to Friday between 9am – 5pm.

• There are no deliveries on weekends or public holidays.

• Main city centre delivery takes 2 – 5 working days.

• With remote areas deliveries can take up to 7 working days.

• Your delivery address should be at an address where somebody you trust will be available to accept your order at any time. Anyone at the delivery address can accept the delivery. In order for us to prove that delivery of an order has been completed, we do not have to prove that you personally received the goods, but rather that any person at the delivery address signed for the delivery.

Delivery Areas 
Currently, we deliver exclusively within South Africa. We are working diligently to expand our reach and hope to serve international customers in the future.

Changes to Orders 
If you need to make any changes to your order, please contact us immediately. We will do our best to accommodate your request, provided the order has not yet been dispatched.

Delivery Insurance
We offer the option of delivery insurance coverage at an additional cost. (Kindly inquire for a quote). The insurance will cover any loss or damage to your shipped products. Once your delivery has been shipped we cannot accept responsibility for lost, stolen, or damaged goods in transit. Any loss or damage without insurance will be at the loss or expense of the customer, so it is advised to accept insurance coverage.

Late Deliveries
Unforeseen circumstances e.g. adverse weather, closed roads, strikes etc. could prolong the delivery time. This is rare but it does happen, so 'late' delivery is not grounds for refund or cancellation of the order. However, if your delivery has not been delivered after the estimated times shown above please contact us with your order number so that we can follow up on the matter. We will also provide you with a tracking number so you can follow your order.

Collections:
If you have selected the “collection” option on checkout. Kindly allow 1-2 working days for the order to be processed. Once the order is ready you will be notified via email or WhatsApp that your order is ready for collection.
Please take note of our trading hours, we do not accommodate any collections after hours.

The provision of goods and services by Lifestyle Health is subject to availability. In cases of unavailability, Lifestyle Health will contact the customer with alternative options.

Thank you for choosing Lifestyle Health. We appreciate your business and look forward to serving your health needs!